Natural Extracts
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Date:2013-09-30 From:

English NameHonokiol

Product Specification2%-90

Test MethodHPLC

CAS NO.35354-74-6

Appearance】:Off-White or white powder or crystal

Molecular formula, molecular weight】:C18H18O2266.33

Extract part】:bark of Mangnolia officinalis

Alias】:3',5-2-2 - allyl - 11 '- biphenyl 2 -4 '- two phenol53-Diallyl-24-dihydroxybiphenyl

Properties】:Colorless scaly crystal, Melting point 87.5 . optical rotation±0°cm-1328016101500882826 Soluble in common organic solventsinteract with ferric chloride in chloroform and will turn into blue.

Total phenol lMagnolia  officinalis

Function Attending】:eliminating dampness, dissolving phlegmremove the intestinal impactionUsed for wet hysteresis injuryvomiting and diarrhea,abdominal distension, constipationphlegm and retained fluid and dyspnea with cough

its apozem can restrain a variety of pathogenic bacteria. Mangnolia officinalis alkali and Isomagnolol have an obvious function to central muscle relaxation. Magnolia bark have decompression effect, When dropping reflection it will cause respiratory excited, heart rate increase.

Pharmacologic Action

1Pharmacological action related to efficacy attending  Mangnolia officinalis can eliminate dampness,remove food retention , resolve stagnation and relieve asthma.

(1) Adjust gastrointestinal motility

In vitro test show thatMangnolia officinalis decoctum can excite intestinal muscle of rabbit, Mice intestinal canal can also be excited within certain range dose, but it will be restrained if adding doseAs guinea pig intestinal canal, it has the same function as it to mice, Excitatory effect is not obvious but inhibition function is more significant. Magnolia officinalis phenol has certain inhibitio to Duodenal spasm caused by histamine.

(2) Anti-ulcer

Raw product magnolia officinalis decoctionGinger main magnolia officinalis decoctionmagnolol

and honokiol have an obvious inbibition to a variety of experimental gastric ulcer animal model, Magnolia officinalis antiulcer effect is related to its inhibition of too much gastric acid secretion.

(3)Protect liver

Magnolia officinalis protect these mouses who have toxic hepatitis , acute liver injury , Immunological liver fibrosis damage.  It can reduce the liver cell degeneration necrosis Magnolia officinalis phenol as the main effective components.

(4) Antibacterial antiviral

Magnolol has a significant antimicrobial activity to gram positive bacteria, acid resistance bacteria, bacillus anthracis, Kind of yeast filamentous fungi, streptococcus mutans and lactobacillus. Phenol in Mangnolia officinalis, ethyl ether and methanol extract have obvious antibacterial effects to streptococcus mutans which cause decayed tooth in odontopathy. Magnolia officinalis have a certain degree of inhibition on mice experimental viral hepatitis , reducing cell degeneration necrosis substantive pathological damage. Neolignan contained in Mangnolia officinalis can suppress Epstein-Barr’s activation

(5) Anti-inflammatory and analgesic

Magnolia officinalis ethanol extract has an obvious inhibition to the increase of mice’s blood capillary permeability of the abdominalin caused by acetic acid, auricular swelling caused by dimethylbenzene , foot swelling caused by carrageenan as well as writhing response and thermal pain stimulus guy reaction caused by acetic acid in mice. It proves that magnolia officinalis alcohol soluble ingredient has better anti-inflammatory and analgesic action

2Other pharmacological effects

(1) Central inhibition and muscle pine

Magnolia officinalis phenol, honokiol and magnolia officinalis ether extract has obvious central inhibitionSignificantly reduce the independent activity of miceand against methamphetamine or apomorphine of central excited. Magnolia bark extract have inhibition to brainstem reticular structure activation system and under the awakening of the thalamus central. Magnolia officinalis phenol could significantly inhibit central excitability amino acid glutamic acid produced by the role of inhibition of the spinal cord. Magnolia officinalis phenol and honokiol have central muscle loose action ,a strong inhibition spinal cord reflection, but large dose can be judged by better antagonism, thinking they belong to non curare kind of muscle loose agent, Magnolia officinalis base intravenous injection can block animal nerve motor end plate transfer, make striated muscle relaxation , And there is no quick resistance phenomenon This role is similar to intravenous injection Intravenous tubocurarine , neostigmine can fight against the muscle loose reaction. So that Magnolia officinalis base may belong to non depolarizing type skeletal muscle relaxation agent having the same function with tubocurarine

(2) inhibition of platelet aggregation

Magnolol and honokiol can significantly restrain the rabbit platelet rich plasma gathering inducing by collagen and arachidonic acid, ATP release. The inhibition is related to the synthesis of inhibit thrombus hydride element A2 (TXA2) and the flow of intracellular ca2 +

(3) Decompression, vascular smooth muscle relaxation

Dosage of magnolia officinalis less than muscle loose injection can significantly reduce blood pressure,this function cannot be against by antihistamines promethazine. The active components magnolia officinalis phenol and honokiol in magnolia bark extract can resist the Rat aorta contraction of the article caused by K +, Ca2 +, norepinephrine, etc, it may matters to Calcium channel block. To sum up, pharmacological action related to the functions like eliminating dampness, dissolving phlegmremove the intestinal impaction are as following: Adjusting gastrointestinal movement, Promoting the secretion of digestive fluid, liver protection, anti-ulcer, Anti-virus, anti-inflammatory, analgesia and so on.